Sebastian Roemer

Sebastian Roemer

Doktorand (Clinician Scientist Program)

Akademischer Werdegang

Seit 2021                Clinician Scientist Researcher, Institute for Stroke and Dementia Research, LMU Uniklinik, München, Deutschland (Supervision: Dr. N. Franzmeier)

Since 2021              Resident, Department of Neurology, LMU Uniklinik München, Deutschland

06/2024-12/2024   Clinician Scientist im Franzmeier Labor gefördert vom FöFoLe Grant der Ludwig-Maximilians Universität für                                                 excellent early career clinician scientists

2021 – 2024            MD, Department of Neuroradiology, Technische Universität München (TUM), Deutschland

2014 – 2021            Medizinstudium Ludwig-Maximilians Universität (LMU), München, Deutschland

2010 – 2013            Bachelor of Science in Human and Molecular Biology, Universiität Saarland, Saarbruecken, Deutschland
 

Publications

Roemer SN, Brendel M, Gnörich J, Malpetti M, Zaganjori M, Quattrone A, Gross M, Steward A, Dewenter A, Wagner F, Dehsarvi A, Ferschmann C, Wall S, Palleis C, Rauchmann BS, Katzdobler S, Jäck A, Stockbauer A, Fietzek UM, Bernhardt AM, Weidinger E, Zwergal A, Stöcklein S, Perneczky R, Barthel H, Sabri O, Levin J, Höglinger GU, Franzmeier N. Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies. Brain. 2024 Jul 5;147(7):2428-2439. doi: 10.1093/brain/awae174. PMID: 38842726.
 
Roemer SN*,Malpetti M*, Harris S*, Gross M, Gnörich J, Stephens A, Dewenter A, Steward A, Biel D, Dehsarvi A, Wagner F, Müller A, Koglin N, Weidinger E, Palleis C, Katzdobler S, Rupprecht R, Perneczky R, Rauchmann BS, Levin J, Höglinger GU, Brendel M, Franzmeier N. Neuroinflammation Parallels 18F-PI-2620 Positron Emission Tomography Patterns in Primary 4-Repeat Tauopathies. Mov Disord. 2024 Jul 18. doi: 10.1002/mds.29924. Epub ahead of print. PMID: 39022835. * equal contributions

Roemer S, Friedrich EB, Kettner M, Rauzi M, Schub P, Kulikovski J, Janitschke D, Stögbauer J, Lochner P. Transorbital sonography and MRI reliability to assess optic nerve sheath diameter in idiopathic intracranial hypertension. J Neuroimaging. 2023 May-Jun;33(3):375-380. doi: 10.1111/jon.13092. Epub 2023 Mar 1. PMID: 36859645.

Quattrone A, Franzmeier N, Huppertz HJ, Klietz M, Roemer SN, Boxer AL, Levin J, Höglinger GU; AL108231 Investigators, the Tauros MRI Investigators, the PASSPORT Study Group, the DESCRIBEPSP Group. Magnetic Resonance Imaging Measures to Track Atrophy Progression in Progressive Supranuclear Palsy in Clinical Trials. Mov Disord. 2024 Jun 2. doi: 10.1002/mds.29866. Epub ahead of print. PMID: 38825840.

Franzmeier N, Dehsarvi A, Steward A, Biel D, Dewenter A, Roemer SN, Wagner F, Groß M, Brendel M, Moscoso A, Arunachalam P, Blennow K, Zetterberg H, Ewers M, Schöll M. Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease. Nat Commun. 2024 Jan 3;15(1):202. doi: 10.1038/s41467-023-44374-w. PMID: 38172114; PMCID: PMC10764818.

Steward A, Biel D, Dewenter A, Roemer S, Wagner F, Dehsarvi A, Rathore S, Otero Svaldi D, Higgins I, Brendel M, Dichgans M, Shcherbinin S, Ewers M, Franzmeier N. ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels. JAMA Neurol. 2023 Dec 1;80(12):1295-1306. doi: 10.1001/jamaneurol.2023.4038. PMID: 37930695; PMCID: PMC10628846.

Biel D, Suárez-Calvet M, Hager P, Rubinski A, Dewenter A, Steward A, Roemer S, Ewers M, Haass C, Brendel M, Franzmeier N; Alzheimer's Disease Neuroimaging Initiative (ADNI). sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease. EMBO Mol Med. 2023 Feb 8;15(2):e16987. doi: 10.15252/emmm.202216987. Epub 2023 Jan 9. PMID: 36620941; PMCID: PMC9906389.

Steward A, Biel D, Brendel M, Dewenter A, Roemer S, Rubinski A, Luan Y, Dichgans M, Ewers M, Franzmeier N; Alzheimer's Disease Neuroimaging Initiative (ADNI). Functional network segregation is associated with attenuated tau spreading in Alzheimer's disease. Alzheimers Dement. 2023 May;19(5):2034-2046. doi: 10.1002/alz.12867. Epub 2022 Nov 25. PMID: 36433865.

Frontzkowski L, Ewers M, Brendel M, Biel D, Ossenkoppele R, Hager P, Steward A, Dewenter A, Römer S, Rubinski A, Buerger K, Janowitz D, Binette AP, Smith R, Strandberg O, Carlgren NM, Dichgans M, Hansson O, Franzmeier N. Earlier Alzheimer's disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading. Nat Commun. 2022 Aug 20;13(1):4899. doi: 10.1038/s41467-022-32592-7. PMID: 35987901; PMCID: PMC9392750.

Biel D, Luan Y, Brendel M, Hager P, Dewenter A, Moscoso A, Otero Svaldi D, Higgins IA, Pontecorvo M, Römer S, Steward A, Rubinski A, Zheng L, Schöll M, Shcherbinin S, Ewers M, Franzmeier N; Alzheimer’s Disease Neuroimaging Initiative. Combining tau-PET and fMRI meta-analyses for patient-centered prediction of cognitive decline in Alzheimer's disease. Alzheimers Res Ther. 2022 Nov 7;14(1):166. doi: 10.1186/s13195-022-01105-5. PMID: 36345046; PMCID: PMC9639286.

Dewenter, A., Steward, A., Dehsarvi, A., Biel, D., Roemer, S. N., Wanger, F., & Franzmeier, N. (2023, July). Effects of cerebrovascular disease on tau progression and cognitive decline in Alzheimer’s disease. In Alzheimer's Association International Conference. ALZ.

Maskos, A., Schmidbauer, M. L., Kunst, S., Rehms, R., Putz, T., Römer, S., ... & Dimitriadis, K. (2022). Diagnostic Utility of Temporal Muscle Thickness as a Monitoring Tool for Muscle Wasting in Neurocritical Care. Nutrients, 14(21), 4498.

Knodel, S., Roemer, S. N., Moslemani, K., Wykrota, A., Käsmann-Kellner, B., Seitz, B., ... & Lochner, P. (2021). Sonographic and ophthalmic assessment of optic nerve in patients with idiopathic intracranial hypertension: A longitudinal study. Journal of the Neurological Sciences, 430, 118069.
 

Poster Präsentationen, Talks und Preise

FöFoLe Grant der Ludwig-Maximilians Universität für hervorragende Early Career Clinician Scientists (60.000€)

Roemer, SN (2022) “Subcortical tau pathology induces cortical neuronal dysfunction in 4R-tauopathies” [Talk], Alzheimer’s Association International Conference, San Diego, USA

Roemer, SN (2023) “Amyloid-induced changes in neuronal activity and connectivity promote tau-spreading in AD” [Poster Presentation], Alzheimer’s Association International Conference, Amsterdam, Niederlande

CurePSP Conference, 2023, London, England

Roemer, SN (2023). “Across schizophrenia spectrum: reduced basolateral and superficial amygdala nuclei volumes only in schizophrenia, specifically linked with positive symptoms” [Poster Presentation] Organization of Human Brain Mapping International Conference 2023, Montreal, Kanada

Roemer, SN (2024) “Amyloid-induced changes in neuronal activity and connectivity promote tau-spreading in AD” [Poster Presentation], Human Amyloid Imaging International Conference, Miami, USA

Roemer, SN (2024) “Alpha Synuclein Co-pathology is associated with faster Ab-related tau accumulation in Alzheimer’s disease” [Poster Presentation], Alzheimer’s Association International Conference, Philadelphia, USA

Roemer, SN (2024) “Amyloid-induced changes in neuronal activity and connectivity promote tau-spreading in AD” [Poster Presentation], Organization of Human Brain Mapping International Conference 2024, Seoul, Südkorea
   
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Folge Sebastian auf X: https://x.com/RoemerSeb

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