Academic education
Since 2021 Clinician Scientist Researcher, Institute for Stroke and Dementia Research, LMU University Hospital, Munich, Germany (Supervision: Dr. N. Franzmeier)
Since 2021 Resident, Department of Neurology, LMU University Hospital Munich, Germany
06/2024-12/2024 Clinician Scientist at Franzmeier Lab at Ludwig Maximilians University, Munich, Germany
(supported by FöFoLe Grant for excellent early career clinician scientists)
2021 – 2024 MD thesis, Department of Neuroradiology, Technical University Munich (TUM)
2014 – 2021 Medical studies, Ludwig-Maximilians University (LMU), Munich, Germany
2010 – 2013 Bachelor of Science in human and molecular biology, University of Saarland, Saarbruecken, Germany
Publications
Roemer SN, Brendel M, Gnörich J, Malpetti M, Zaganjori M, Quattrone A, Gross M, Steward A, Dewenter A, Wagner F, Dehsarvi A, Ferschmann C, Wall S, Palleis C, Rauchmann BS, Katzdobler S, Jäck A, Stockbauer A, Fietzek UM, Bernhardt AM, Weidinger E, Zwergal A, Stöcklein S, Perneczky R, Barthel H, Sabri O, Levin J, Höglinger GU, Franzmeier N. Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies. Brain. 2024 Jul 5;147(7):2428-2439. doi: 10.1093/brain/awae174. PMID: 38842726.
Roemer SN*,Malpetti M*, Harris S*, Gross M, Gnörich J, Stephens A, Dewenter A, Steward A, Biel D, Dehsarvi A, Wagner F, Müller A, Koglin N, Weidinger E, Palleis C, Katzdobler S, Rupprecht R, Perneczky R, Rauchmann BS, Levin J, Höglinger GU, Brendel M, Franzmeier N. Neuroinflammation Parallels 18F-PI-2620 Positron Emission Tomography Patterns in Primary 4-Repeat Tauopathies. Mov Disord. 2024 Jul 18. doi: 10.1002/mds.29924. Epub ahead of print. PMID: 39022835. * equal contributions
Roemer S, Friedrich EB, Kettner M, Rauzi M, Schub P, Kulikovski J, Janitschke D, Stögbauer J, Lochner P. Transorbital sonography and MRI reliability to assess optic nerve sheath diameter in idiopathic intracranial hypertension. J Neuroimaging. 2023 May-Jun;33(3):375-380. doi: 10.1111/jon.13092. Epub 2023 Mar 1. PMID: 36859645.
Quattrone A, Franzmeier N, Huppertz HJ, Klietz M, Roemer SN, Boxer AL, Levin J, Höglinger GU; AL‐108‐231 Investigators, the Tauros MRI Investigators, the PASSPORT Study Group, the DESCRIBE‐PSP Group. Magnetic Resonance Imaging Measures to Track Atrophy Progression in Progressive Supranuclear Palsy in Clinical Trials. Mov Disord. 2024 Jun 2. doi: 10.1002/mds.29866. Epub ahead of print. PMID: 38825840.
Franzmeier N, Dehsarvi A, Steward A, Biel D, Dewenter A, Roemer SN, Wagner F, Groß M, Brendel M, Moscoso A, Arunachalam P, Blennow K, Zetterberg H, Ewers M, Schöll M. Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease. Nat Commun. 2024 Jan 3;15(1):202. doi: 10.1038/s41467-023-44374-w. PMID: 38172114; PMCID: PMC10764818.
Steward A, Biel D, Dewenter A, Roemer S, Wagner F, Dehsarvi A, Rathore S, Otero Svaldi D, Higgins I, Brendel M, Dichgans M, Shcherbinin S, Ewers M, Franzmeier N. ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels. JAMA Neurol. 2023 Dec 1;80(12):1295-1306. doi: 10.1001/jamaneurol.2023.4038. PMID: 37930695; PMCID: PMC10628846.
Biel D, Suárez-Calvet M, Hager P, Rubinski A, Dewenter A, Steward A, Roemer S, Ewers M, Haass C, Brendel M, Franzmeier N; Alzheimer's Disease Neuroimaging Initiative (ADNI). sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease. EMBO Mol Med. 2023 Feb 8;15(2):e16987. doi: 10.15252/emmm.202216987. Epub 2023 Jan 9. PMID: 36620941; PMCID: PMC9906389.
Steward A, Biel D, Brendel M, Dewenter A, Roemer S, Rubinski A, Luan Y, Dichgans M, Ewers M, Franzmeier N; Alzheimer's Disease Neuroimaging Initiative (ADNI). Functional network segregation is associated with attenuated tau spreading in Alzheimer's disease. Alzheimers Dement. 2023 May;19(5):2034-2046. doi: 10.1002/alz.12867. Epub 2022 Nov 25. PMID: 36433865.
Frontzkowski L, Ewers M, Brendel M, Biel D, Ossenkoppele R, Hager P, Steward A, Dewenter A, Römer S, Rubinski A, Buerger K, Janowitz D, Binette AP, Smith R, Strandberg O, Carlgren NM, Dichgans M, Hansson O, Franzmeier N. Earlier Alzheimer's disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading. Nat Commun. 2022 Aug 20;13(1):4899. doi: 10.1038/s41467-022-32592-7. PMID: 35987901; PMCID: PMC9392750.
Biel D, Luan Y, Brendel M, Hager P, Dewenter A, Moscoso A, Otero Svaldi D, Higgins IA, Pontecorvo M, Römer S, Steward A, Rubinski A, Zheng L, Schöll M, Shcherbinin S, Ewers M, Franzmeier N; Alzheimer’s Disease Neuroimaging Initiative. Combining tau-PET and fMRI meta-analyses for patient-centered prediction of cognitive decline in Alzheimer's disease. Alzheimers Res Ther. 2022 Nov 7;14(1):166. doi: 10.1186/s13195-022-01105-5. PMID: 36345046; PMCID: PMC9639286.
Dewenter, A., Steward, A., Dehsarvi, A., Biel, D., Roemer, S. N., Wanger, F., & Franzmeier, N. (2023, July). Effects of cerebrovascular disease on tau progression and cognitive decline in Alzheimer’s disease. In Alzheimer's Association International Conference. ALZ.
Maskos, A., Schmidbauer, M. L., Kunst, S., Rehms, R., Putz, T., Römer, S., ... & Dimitriadis, K. (2022). Diagnostic Utility of Temporal Muscle Thickness as a Monitoring Tool for Muscle Wasting in Neurocritical Care. Nutrients, 14(21), 4498
Knodel, S., Roemer, S. N., Moslemani, K., Wykrota, A., Käsmann-Kellner, B., Seitz, B., ... & Lochner, P. (2021). Sonographic and ophthalmic assessment of optic nerve in patients with idiopathic intracranial hypertension: A longitudinal study. Journal of the Neurological Sciences, 430, 118069.
Poster presentations, talks and awards
FöFoLe Grant of the Ludwig-Maximilians University for excellent early career clinician scientists (60.000€)Roemer, SN (2022) “Subcortical tau pathology induces cortical neuronal dysfunction in 4R-tauopathies” [Talk], Alzheimer’s Association International Conference, San Diego, USARoemer, SN (2023) “Amyloid-induced changes in neuronal activity and connectivity promote tau-spreading in AD” [Poster Presentation], Alzheimer’s Association International Conference, Amsterdam, NetherlandsCurePSP Conference, 2023, London, EnglandRoemer, SN (2023). “Across schizophrenia spectrum: reduced basolateral and superficial amygdala nuclei volumes only in schizophrenia, specifically linked with positive symptoms” [Poster Presentation] Organization of Human Brain Mapping International Conference 2023, Montreal, CanadaRoemer, SN (2024) “Amyloid-induced changes in neuronal activity and connectivity promote tau-spreading in AD” [Poster Presentation], Human Amyloid Imaging International Conference, Miami, USARoemer, SN (2024) “Alpha Synuclein Co-pathology is associated with faster Ab-related tau accumulation in Alzheimer’s disease” [Poster Presentation], Alzheimer’s Association International Conference, Philadelphia, USARoemer, SN (2024) “Amyloid-induced changes in neuronal activity and connectivity promote tau-spreading in AD” [Poster Presentation], Organization of Human Brain Mapping International Conference 2024, Seoul, South KoreaGoogle ScholarFollow Sebastian on X:
https://x.com/RoemerSebphoto@Nikolaus.Brade
